Identification and spatial distribution of glycine receptor subunits in human sperm

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Identification and spatial distribution of glycine receptor subunits in human sperm.

The human sperm surface glycine receptor (GLR) plays a role in an important fertilization event, the sperm acrosome reaction. Here, by western blot analysis, we report the presence of GLRA1, GLRA2, GLRA3, and GLRB subunits in human sperm. Immunolocalization studies showed that the GLRA1 and GLRA2 subunits are present in the equatorial region, the GLRA3 subunit in the flagellar principal piece, ...

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Glycine Receptor Genes and Subunits

amino acid triplet codons engage different transfer RNAs. These enzyme machineries thus allow for diversifi cation of the proteome or even correction of the genome code. Although the role of diversifi cation by cytidine-to-uracil (C-to-U) RNA editing in generation of immunoglobulin variability is under debate (Honjo et al., 2005) the critical impact of RNA editing on correction of genome codes ...

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background: γ-aminobutyric acid (gaba) is considered to be the predominant inhibitory neurotransmitter in mammalian central nervous systems (cns). there are two major classes of gaba receptors: gabaars and gababrs. the gabaa receptor is derived from various subunits such as alpha1-alpha 6, beta1-beta 3, gamma1-gamma 4, delta, epsilon, pi, and rho1-3. intensive research has been performed to un...

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Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the glycine current. In retinal amacrine and gangl...

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ژورنال

عنوان ژورنال: REPRODUCTION

سال: 2008

ISSN: 1470-1626,1741-7899

DOI: 10.1530/rep-08-0223